02/10/2024 - Press release
· Chronic obstructive pulmonary disease (COPD) patients who die had, years earlier, a higher presence of about thirty proteins in their blood related to inflammation and coagulation. · Detecting these proteins allows for a very accurate prediction of future mortality risk in patients with stable COPD, according to a multicenter pilot study led by Hospital del Mar, recently published in the journal Cells. · Researchers used various models to predict mortality risk through an AI-assisted program developed by the Biomedical Informatics Research Group at Pompeu Fabra University (UPF) and the Hospital del Mar Research Institute, one of which reached a precision level of 95%.
Més informació "Blood markers identified to predict long-term mortality in stable COPD patients"
20/09/2024 - Press release
The oxidation of low-density lipoproteins present in the blood (LDL) or bad cholesterol opens the door to an increased cardiovascular risk, as this oxidized cholesterol is more likely to deposit in the arteries, leading to the growth of cholesterol plaques that cause arteriosclerosis. Engaging in intense physical activity reduces the oxidation of LDL particles, lowering the risk of cardiovascular disease. Thirty minutes of intense exercise daily reduces oxidized LDL cholesterol by 8 to 10%. However, the effect is only seen in men. Low or moderate intensity exercises do not have the same effect. This is revealed by a study from the Hospital del Mar Research Institute and the Faculty of Medicine of the University of Vic-Central University of Catalonia, published in the Revista Española de Cardiología.
Més informació "Intense physical exercise reduces levels of the worst part of bad cholesterol"
05/09/2024 - Press release
For women who have been admitted to a hospital for a mental disorder, the risk of suicide is 48 times higher than in the general female population. For men in the same situation, the risk is 28 times higher, according to a study by the Hospital del Mar Research Institute published in JAMA Network Open. The risk of premature death, meaning dying before the age of 70, is also higher in people hospitalized for a mental disorder. This group has nearly eight times the mortality risk compared to the rest of the population. The study analyzed data from nearly 50,000 people. The disorders with the most impact are depression, cognitive disorders, adjustment and bipolar disorders, and alcohol use.
07/08/2024 - Press release
A 10% increase in blood sugar levels from the usual raises the likelihood of a poor prognosis by 7% and the chance of death by 10% within three months of the stroke, according to a study published in Cardiovascular Diabetology. The study reviewed data from nearly 3,000 patients treated for this condition at Hospital del Mar. Research will continue to determine if managing glucose levels in this population can improve their prognosis.
Més informació "Higher Glucose Levels Worsen Prognosis in Ischemic Stroke Patients"
23/07/2024 - Press release
Chest ultrasound enables quick and easy identification of patients who may have a worse prognosis due to pneumonia caused by SARS-CoV-2 infection. The published work is a collaboration between Hospital del Mar and Doctors Without Borders, published in the Journal of Clinical Medicine. This diagnostic tool, with proper training and access to portable ultrasound devices, is particularly useful in resource-limited countries due to its ease of bedside use.
10/07/2024 - Press release
A study published in Science Advances identifies a set of microproteins that are exclusively produced in liver tumors. This makes them a clear target for immune system cells and a potential target for cancer vaccine development. The research was led by the Evolutionary Genomics Research Group at the Hospital del Mar Research Institute, in collaboration with Cima University of Navarra and Pompeu Fabra University. Various state-of-the-art tools were used to detect and identify these small molecules in samples from over a hundred tumors.
Més informació "Microproteins Found in Tumors Could Lead to Cancer Vaccines"
12/07/2024 - Press release
The new method would allow for a more objective and precise classification of patients' types of osteoarthritis, supported by data mining techniques and biological modeling, which enable the analysis and processing of large volumes of information. Pompeu Fabra University (UPF) and Hospital del Mar have designed a new method to classify the types of knee osteoarthritis that patients suffer from in a more objective and precise way.
27/06/2024 - Press release
Gastric bypass is more effective than the other common approach, vertical sleeve gastrectomy, in reducing LDL cholesterol levels. This is a common comorbidity in patients undergoing this type of surgery and a primary agent causing atherosclerosis. This is revealed in a study by the Bariatric Surgery Unit at Hospital del Mar, published in the journal Cardiovascular Diabetology. The study's authors argue that this fact should be considered when deciding which technique to use for each patient.
05/06/2024 - Press release
A scientific team led by Dr Anna Bigas, from the Hospital del Mar Research Institute and the Josep Carreras Institute, has described the role of the IκBα protein in the differentiation process of haematopoietic cells. In the absence of this protein, the stem cells enter quiescence, acquire a dormant state and maintain their potential, which may allow them to be transplanted for therapeutic uses in leukaemia or blood diseases of genetic origin. This is an important step towards being able to generate these types of cells in the lab, preventing them from differentiating and turning into other cells too early.
29/05/2024 - Press release
An international study led by the Hospital del Mar Medical Research Institute has demonstrated, for the first time, the role of two proteins in the activation and deactivation of the system through which drugs act against schizophrenia symptoms. These two proteins are potential targets for developing new drugs aimed at specific symptoms of the disease, avoiding the side effects of current treatments. The study analyzed how certain molecules act on a serotonin cell receptor, which could allow for differentiated effects on schizophrenia symptoms without affecting other brain processes.
Més informació "New Avenues to Developing Personalized Treatments for Schizophrenia"
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