06/11/2025 - Press release
A systematic review of published studies on service coverage for these conditions in adults, published in The Lancet Regional Health - Europe, reveals this gap. Overall, there is little information about the capacity to provide care for people with mental disorders across European countries. Existing data show great disparities between nations and generally low coverage for nearly all disorders. These figures put at risk the World Health Organization's goal of increasing coverage for these patients by 50% by 2030.
31/10/2025 - Press release
An international study published in Brain, Behavior, and Immunity shows that patients with treatment-resistant depression (TRD) have a unique biology, different from those who respond to standard therapies. More than 5,000 genes were found to behave differently in TRD compared with non-resistant patients. The study reports the first results of the PROMPT consortium, which aims to combine clinical and molecular data using machine learning to predict which patients are at risk of developing TRD.
Més informació "Treatment-resistant depression identified as a distinct molecular subtype"
16/10/2025 - Press release
Greater exposure of mothers to airborne particulate matter during pregnancy is linked to lower levels of brain myelination in newborns. This is highlighted by the first study to measure neonatal brain myelination using magnetic resonance imaging (MRI). Published in the journal Environment International, it is the result of a collaboration between Hospital del Mar and ISGlobal. The research shows that prenatal exposure to fine particles (PM2.5) is associated with slower brain maturation during the first month of life. Myelination is a key marker of brain development.
10/10/2025 - Press release
Stress sensitivity increases the frequency, intensity, and variability of suicidal thoughts among the university community. These are the findings of a longitudinal study coordinated by the Hospital del Mar Research Institute and Pompeu Fabra University, which analyses survey data from more than 700 university students. The study defines, for the first time, three degrees of passive suicidal ideation according to their frequency, intensity and increasing variability. Taking stress sensitivity into account could have an impact on suicide prevention.
10/09/2025 - Press release
Young people beginning university show a much higher prevalence of suicidal thoughts and attempts compared to the general population, according to an international study led by the Hospital del Mar Research Institute. The study, part of the World Mental Health International College Student Initiative led by Harvard University, invited nearly 73,000 students from 71 universities in eighteen countries to participate. It is the most comprehensive study conducted to date on this population. Experiencing traumatic events during childhood and having parents with mental health disorders are the main risk factors for suicidal behavior. In addition, transgender students are 2.4 times more likely to experience suicidal thoughts than other students.
09/09/2025 - Press release
A study published in Science identifies the complementary role of the main families of neurons in representing the environment. The work, coordinated by Dr. Manuel Valero, head of the Neural Computation Laboratory at the Hospital del Mar Research Institute, presents an open-access tool to analyze neuronal diversity. The tool is already freely available and can be applied to the study of other brain regions and of diseases such as Alzheimer's, epilepsy, major depression, and Down syndrome, paving the way for more specific therapeutic strategies.
Més informació "An artificial intelligence tool reveals how the brain orients itself in space"
05/08/2025 - Press release
70% of Chronic Obstructive Pulmonary Disease (COPD) cases go undiagnosed. Now, a study led by Hospital del Mar and the Hospital del Mar Research Institute has validated ten metabolites that are altered in patients with this disease. These metabolites can be identified through a simple blood test, which opens the door to their use in future population-based screening for suspected COPD. The study used artificial intelligence tools to determine which of these molecules yielded the most accurate results.
Més informació "Progress Toward a Population Screening Test for COPD"
31/07/2025 - Press release
This is indicated by the results of the PENSA study, a clinical trial conducted jointly by the Research Institute of Hospital del Mar and the Barcelonaβeta Brain Research Center, the research center of the Pasqual Maragall Foundation. The study concludes that combining a healthy lifestyle program with epigallocatechin gallate (EGCG), a natural compound found in green tea, could offer sustained cognitive benefits in people at high risk of developing Alzheimer's disease. Over the course of one year, around one hundred cognitively healthy volunteers, but in stages potentially prior to the onset of dementia, were monitored. They were divided into three groups. One group received only healthy lifestyle advice. The other two groups underwent a lifestyle improvement intervention program combined with either EGCG or placebo.
25/07/2025 - Press release
Researchers from the Hospital del Mar Research Institute and Yale University, in the United States, have demonstrated how the action of certain genes on precursor cells of brain formation can cause alterations linked to cortical malformations but also to the origin of neuropsychiatric diseases such as autism or bipolar disorder. The study, published in Nature Communications, is the first of its kind. It has been able to simulate the function of a list of nearly 3,000 genes linked to these pathologies during human brain development.
16/07/2025 - Press release
These molecules act as small building blocks that regulate the cellular response by switching certain internal signals on or off. This is the conclusion of an international study led by the Hospital del Mar Research Institute, published in the journal Nature Communications. The findings may help develop more precise drugs to treat various diseases more effectively, while avoiding side effects.
Més informació "Amino acids play a key role in how cells respond to drugs"
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