04/11/2025 - General information
The project aims to optimize the use of the new antibiotic aztreonam-avibactam in patients with renal impairment. It has been selected within the program "Independent Research Grant Program - Pharmacokinetics-pharmacodynamics (PK/PD) of Aztreonam-Avibactam (ATM-AVI) in Special Populations", promoted by the American pharmaceutical company.
The Pharmacokinetics and Pharmacodynamics (PK/PD) Research Team at Hospital del Mar has received a competitive international grant awarded by the pharmaceutical company Pfizer, as part of the "Independent Research Grant Program - Pharmacokinetics-pharmacodynamics (PK/PD) of Aztreonam-Avibactam (ATM-AVI) in Special Populations." The selected project, chosen among proposals from several European centers, aims to optimize the use of the new antibiotic aztreonam-avibactam in patients with renal impairment - a population particularly vulnerable to severe infections caused by multidrug-resistant bacteria. The project is led by Dr. Mila Montero and Dr. Sònia Luque.
The funding, amounting to 55,200 USD, will make it possible to further study the drug's behavior in patients with different degrees of renal impairment, with the goal of establishing safer and more effective dosing regimens. "This recognition highlights Hospital del Mar's commitment to improving the treatment of severe infections in complex patients," emphasizes Dr. Mila Montero, Head of the Nosocomial Infections Section of the Infectious Diseases Department and researcher at the Hospital del Mar Research Institute. Meanwhile, Dr. Sònia Luque, consultant at the Pharmacy Department, points out that "the results of this study will help optimize the use of a key antibiotic against resistant microorganisms, improving patient care and outcomes in critical cases."
Pfizer's grant program aims to promote independent research in areas of high clinical relevance. In this edition, projects from several European countries have been selected, with a total funding of 300,000 USD.
From left to right: Mila Montero, Juan Pablo Horcajada, Sandra Domene, Sònia Luque, and Eduardo Padilla.
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