31/07/2025 - Press release
This is indicated by the results of the PENSA study, a clinical trial conducted jointly by the Research Institute of Hospital del Mar and the Barcelonaβeta Brain Research Center, the research center of the Pasqual Maragall Foundation. The study concludes that combining a healthy lifestyle program with epigallocatechin gallate (EGCG), a natural compound found in green tea, could offer sustained cognitive benefits in people at high risk of developing Alzheimer's disease. Over the course of one year, around one hundred cognitively healthy volunteers, but in stages potentially prior to the onset of dementia, were monitored. They were divided into three groups. One group received only healthy lifestyle advice. The other two groups underwent a lifestyle improvement intervention program combined with either EGCG or placebo.
29/07/2025 - Institutional news
One of the symptoms associated with long COVID is chronic fatigue. Until now, its origin was unclear. A study conducted by the Pneumology, Pathology, and Intensive Care Services at Hospital del Mar, along with researchers from the Hospital del Mar Research Institute, points to a potential cause: fibrosis in the walls of blood vessels triggered by the infection. The study has been published in the journal Ultrastructural Pathology. The research is based on muscle biopsies taken from the quadriceps of 35 patients admitted to Hospital del Mar during the pandemic. Eight of these samples were analyzed using electron microscopy to assess the state of the tissue. Significant fibrosis was found in the walls of the capillaries supplying blood to the muscle fibers, a finding consistent with observations in other organs from patients who died from COVID-19.
Més informació "One of the Possible Causes of Chronic Fatigue in People with Long COVID Identified"
25/07/2025 - Press release
Researchers from the Hospital del Mar Research Institute and Yale University, in the United States, have demonstrated how the action of certain genes on precursor cells of brain formation can cause alterations linked to cortical malformations but also to the origin of neuropsychiatric diseases such as autism or bipolar disorder. The study, published in Nature Communications, is the first of its kind. It has been able to simulate the function of a list of nearly 3,000 genes linked to these pathologies during human brain development.
21/07/2025 - Events
The project aims to determine the prognostic value of molecules in the tumor microenvironment in melanoma. A project led by Dr. Sònia Segura, attending physician in the Dermatology Department at Hospital del Mar and researcher in the Dermatological Inflammatory and Neoplastic Diseases Research Group at the Hospital del Mar Research Institute, has received one of the Jané Mateu Foundation grants in its third edition. The award ceremony took place on June 25 at the modernist site of Hospital de Sant Pau. The study aims to determine the prognostic value of molecules in the tumor microenvironment in melanoma, specifically a marker related to activation of the TGF-beta pathway, which is associated with the disease's ability to evade the immune system.
Més informació "The Jané Mateu Foundation Awards a Grant to a Project Led by Dr. Sònia Segura"
16/07/2025 - Press release
These molecules act as small building blocks that regulate the cellular response by switching certain internal signals on or off. This is the conclusion of an international study led by the Hospital del Mar Research Institute, published in the journal Nature Communications. The findings may help develop more precise drugs to treat various diseases more effectively, while avoiding side effects.
Més informació "Amino acids play a key role in how cells respond to drugs"
15/07/2025 - Events
The first collaboration day between the Hospital del Mar Research Institute and the Institute for Bioengineering of Catalonia (IBEC) was held today at the Barcelona Biomedical Research Park (PRBB). The meeting provided an opportunity to share research projects, identify areas for collaboration and formalise a strategic alliance through the signing of a collaboration agreement between the Hospital del Mar and the Hospital del Mar Research Institute and IBEC.
Més informació "Hospital del Mar and IBEC formalise a new collaboration"
10/07/2025 - Press release
The journal Cancer Cell has published a study led by the Hospital del Mar Research Institute, together with researchers from GEICAM, identifying malignant cells carrying the TIM-3 protein as a central factor in their ability to generate breast cancer metastasis. This molecule allows cancer cells to survive the most critical and challenging stage of metastasis-when they first reach a new organ-by evading immune system attacks. At the same time, it may serve as a marker of poor prognosis and metastasis risk in patients with TIM-3-positive tumors. This discovery opens the door to the potential use of treatments that block TIM-3 to prevent metastasis before it becomes clinically evident.
02/07/2025 - General information
Levels of butyrate and isobutyrate, short-chain fatty acids produced by the gut microbiota, are associated with a higher risk of developing the disease, according to a study led by IISPV and Hospital del Mar. A research team led by scientists from the Pere Virgili Health Research Institute (IISPV), the Hospital del Mar Research Institute, and the Diabetes and Associated Metabolic Diseases area of the CIBER (CIBERDEM) has identified two compounds present in the blood - butyrate and isobutyrate - that could serve as early predictors of type 2 diabetes in seemingly healthy individuals.
30/06/2025 - General information
The Health Services Research Group at the Hospital del Mar Research Institute of Barcelona (HMRIB) is leading the INSTRUMENTAL project, in collaboration with the General Subdirectorate of Addictions, HIV and Viral Hepatitis (SGAVIHV). The project aims to generate relevant and applicable knowledge about the mental health measurement instruments used in general population studies. This pioneering initiative seeks to optimize how population mental health is assessed.
27/06/2025 - Press release
A study by the Hospital del Mar Research Institute, recently published in the journal PNAS, advances our understanding of how the brain makes decisions by participating in the storage of associations between different stimuli. The research has identified the importance of specific brain areas in these processes, particularly the amygdala and its relationship with parts of the cerebral cortex. This finding could lead to new therapeutic approaches for treating mental disorders such as psychosis or post-traumatic stress disorder (PTSD). The study was conducted on mice, but the researchers believe that the mechanisms involved may be similar in humans.
Més informació "Understanding How the Brain Makes Decisions"
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